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Familial male-limited precocious puberty
1 OMIM reference -
1 associated gene
9 connected diseases
12 signs/symptoms
Disease Type of connection
Leydig cell hypoplasia due to complete LH resistance
Leydig cell hypoplasia due to partial LH resistance
Athyreosis
Dominant hypophosphatemia with nephrolithiasis or osteoporosis
Familial gestational hyperthyroidism
Familial hyperthyroidism due to mutations in TSH receptor
Hypothyroidism due to TSH receptor mutations
Leydig cell hypoplasia due to LHB deficiency
Thyroid hypoplasia
Synonym(s):
- FMPP
- Familial gonadotropin-independent male-limited sexual precocity
- Male-limited precocious puberty
- Testotoxicosis
Classification (Orphanet):
- Rare endocrine disease
Classification (ICD10):
- Endocrine, nutritional and metabolic diseases -
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: childhood
Average age of death: normal
Type of inheritance: autosomal dominant
External references:
1 OMIM reference -
1 MeSH reference: C536961
Gene symbol UniProt reference OMIM reference
LHCGR P22888152790
Very frequent
- Advanced bone age
- Autosomal dominant inheritance
- Precocious puberty
- Sterility / hypofertility
- Tall stature / gigantism / growth acceleration

Frequent
- Acne / acnea
- Hair and scalp anomalies
- Macropenis / megapenis / large penis

Occasional
- Azoospermia / oligospermia / asthenospermia
- Hyperactivity / attention deficit
- Macroorchidism / macrotestes
- Psychic / behavioural troubles